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Early-onset disease (at <50 years of age) accounts for 10% of colorectal cancer cases, and the incidence is increasing, particularly in high-income countries. Patients often present with advanced disease in the left colon. One in six patients has deficient DNA mismatch repair. Screening is now recommended to begin at 45 years of age.
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I thank Bahar Saberzadeh-Ardestani, M.D., for her assistance with the preparation of an earlier version of the manuscript, review of its content, and initial drafts of figures.
From the Departments of Oncology and Medicine, Mayo Clinic Alix School of Medicine, Mayo Comprehensive Cancer Center, Rochester, MN.
Dr. Sinicrope can be contacted at [email protected] or at 200 First St. SW, Rochester, MN 55905.
April 21, 2022
N Engl J Med 2022; 386:1547-1558
DOI: 10.1056/NEJMra2200869
Dan L. Longo, M.D., Editor
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